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KMID : 1023519940170030247
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Korean Journal of Veterinary Service
1994 Volume.17 No. 3 p.247 ~ p.254
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Control of Parturition Time on Pig I. Effect of Parasympathetic Nerve and Cholinergic Agonist on Uterine Smooth Muscle Motility
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Park Sang-Eun
Hwang Bo-Won
Byun You-Sung
Cho Kwang-Je
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Abstract
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To elucidate the action of the cholinergic nerve on the isolated uterine smooth muscle of the pig, effects of electrical transmural nerve stimulation and acetylcholine were investigated on the pretreatment of the physostigmine ; cholinestrase inhibitor and atropine ; cholinergic receptor blocker from physiograph. 1. The contractile response induced by acetylcholine was responsed in the concentration of 10^{-8}$ M at first and the maximum contractility was concentration of M. 2. The contractile response induced by electrical transmural nerve stimulation(20 V, 0.5 Msec, 20 sec) was the frequency(2-64 Hz) -dependent manner. 3. The contractile response induced by acetylcholine was completely blocked by the pretreatment with cholinergic receptor blocker, atropine and was increased by the pretrement of cholinestrase inhibitor, physostigmine. 4. The contractile response induced by electrical transmural nerve stimulation was completely blocked by the pretreatment with cholinergic receptor blocker, atropine, and was increased by the pretretment of cholinestrase inhibitor, physostigmine. These findings suggest that it was powerful excitatory action by cholinergic nerve on uterine smooth muscle of the pig.
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KEYWORD
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Uterine smooth muscle, Parasympathetic nerve, Cholinergic agonist
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