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KMID : 1023519950180020177
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Korean Journal of Veterinary Service
1995 Volume.18 No. 2 p.177 ~ p.181
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Control of Parturition Time on Pig III. Effect of Histamine on Uterine smooth muscle motility
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Park Sang-Eun
Hwang Bo-Won
Byun You-Sung
Cho Kwang-Je
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Abstract
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The effects of histamine were investigated on the uterine smooth muscle motility in the pig. The results were summarized as fellows : 1. Histamine caused the contraction of the porcine uterine smooth muscle and the contractile responses increased between the concetration of histamine and M with a dose-dependent manner. 2. The contractile response Induced by histamine ( M) was completely blocked by pretrevatment with -histaminergic receptor blocker, pyrilamine( M) 3. The contractile response induced by histamine( M) was increased by pretreatment with -histaminergic receptor blocker, cimetidine( M) From these results, it was concluded that the effects of uterine smooth muscle by histamine were the contraction mediated by -histaminergic receptor and the relaxation mediated by -histaminergic receptor in pig.
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KEYWORD
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Uterine smooth muscle motility, Histamine
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