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KMID : 1023519960190020154
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Korean Journal of Veterinary Service
1996 Volume.19 No. 2 p.154 ~ p.162
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Control of Parturition Time on Pig;IV. Effect of ATP on Uterine Smooth Muscle Motility
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Park Sang-Eun
Hwang Bo-Won
Byun You-Sung
Cho Kwang-Je
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Abstract
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The effcets of adenosine 5’-triphosphate(ATP) were investigated on the uterine smooth muscle motility in the pig. The results were summarized as follows: 1. The effects of the porcine uterine smooth muscle and the contractile responses increased between the concentration of ATP and M with a dose-dependent manner. 2. The contractile response induced by ATP( M) was not blocked by pretreatment with cholinergic receptor blocker, atropine ( M) 3. The contractile response induced by ATP ( M) was not blocked by pretreatment with -adrenergic receptor blocker, phentolamine(10 M) and -adrenergic blocker, propranolol ( M). 4. The contractile response induced by ATP( M) was not appeared in -free medium. As the concentration of in -free medium was increased, the contractile response induced by ATP ( M) was enhenced but was completely inhibited by pretreatment with -channel blocker, papaverine( M) or verapamil( M). From these results, it was conclued that the effects of ATP were the contraction mediated by purinergic receptor in uterine smooth muscle of pig.
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KEYWORD
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ATP, Porcine uterine smooth muscle, Purinergic receptor
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