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KMID : 1023520060290010019
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Korean Journal of Veterinary Service
2006 Volume.29 No. 1 p.19 ~ p.26
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The minimum inhibitory concentration (MIC) of bee venom against bacteria isolated from pigs and chickens
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Kim Soon-Tae
Hwang Ji-Young
Sung Myoung-Suk
Je So-Yang
Bae Dong-Rok
Han Sang-Mi
Lee Sung-Hae
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Abstract
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Bee venom is synthesized in the venom gland’s of worker and queen bees and stored in their venom sacs. Bee venom is a rich source of enzymes, peptides and biogenic amines. there are at least 18 active components in the venom which have some pharmaceutical properties. This study was performed to evaluate minimum inhibitory concentration(MIC) of bee venom against bacteria isolated from pjgs and chickens with disease. In case of reference strains, the MIC of Staphylococcus aureus ATCC 6538, Streptococcus mutans ATCC 25175, and Salmonella typhimurium ATCC 6538 were 64, 64 and 32, respectively. In case of bacteria isolated from pig and chicken, the MIC of Staphylococcus aureus, Staphylococcus hyicus and Staphylococcus chromogenes were 8, 128 and 128, and that of 11 strains of Escherichia coli were 8 to >512 and that of 8 strains of Salmonella sup were >512. Antibacterial resistance test of 22 strains isolated from pig and chicken and 3 reference strains were performed by agar gel diffusion method, using 17 antibacterial drugs including penicillin, cefazolin, tetracycline and quinolone group. The multiple drug resistant patterns were found in most strains isolated from pig and chicken.
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KEYWORD
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Bee venom, Minimum inhibitory, concentration (MIC)
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