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KMID : 1023520110340020191
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Korean Journal of Veterinary Service
2011 Volume.34 No. 2 p.191 ~ p.193
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Hemophilia B (factor IX deficiency) in a Labrador retriever dog
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Kim Jun-Hwan
Noh Dong-Ho
Song Ru-Hui
Lee Da-Mi
Cho Ho-Seong
Yu Do-Hyeon
Park Jin-Ho
Park Chul
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Abstract
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A 3-month-old intact male, Labrador retriever was presented with the history of coagulopathy and
anemia. The results of initial screening tests of the hemostatic system yielded a tentative diagnosis of
hemophilia. Activated partial thromboplastin time (APTT) was distinctly prolonged (106 seconds) and
prothrombin time (PT) was not detected due to markedly prolonged test time. Whole blood transfusions
(20 me l/kg body weight) were carried out prior to assays of coagulation factor. After transfusion,
the patient recovered well and hemorrhage ceased. Blood samples were assessed for coagulation
factor activity. The patient showed markedly low factor IX coagulation activity (5%, reference
range: 7∼140%) and was diagnosed with hemophilia B. After recovery, the patient was discharged
from the hospital. However, 4 months later the patient was re-hospitalized for recurrence of the initial
symptoms. The owner did not want to pursue further treatment and the patient died of respiratory distress
two days later.
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KEYWORD
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Hemophilia B, Factor IX, Coagulopathy, Dog
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