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KMID : 1023520140370010019
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Korean Journal of Veterinary Service
2014 Volume.37 No. 1 p.19 ~ p.27
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Prevalence of antimicrobial resistance and integrons in extended, spectrum β-lactamases producing Escherichia coli isolated from Nakdong and Gumho river
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Cho Jae-Keun
Kim Hwan-Deuk
Kwon Soon-Hyo
Jang Sung-Il
Kim Jin-Hyun
Park Choi-Kyu
Kim Ki-Seuk
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Abstract
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This study was conducted to investigate the antimicrobial resistance, presence of β-lactamase genes and integrons in 83 ESBL-producing Escherichia coli isolated from Nakdong river and Geumho river in Daegu. Among the β-lactam antimicrobials, all isolates were resistant to ampicillin, cephalothin, cefamandole and cefotaxime, followed by piperacillin (98.8%), ampicillin/sulbactam (86.7%), aztreonam (60.2%) and cefepime (59.0%), whereas resistance to piperacillin/tazobacram, ticarcillin/clavulanic acid and cefoxitin was less than 30%. Many of the ESBL-producing Escherichia coli were also resistant to non-β-lactams antimicrobials such as nalidixic acid (83.1%), sulfonamides (72.3%), ciprofloxacin (62.7%) and gentamicin (38.6%). All isolates showed resistance to seven or more antimicrobial agents.The most frequently detected gene was blaTEM+CTX-M (49.4%), followed by blaCTX-M (27.7%), blaTEM (6.0%) and blaOXA (1.2%). But blaSHV was not found. Class 1 integrons were found in 61.4% (51 isolates) of isolates, however, class 2 and 3 integrons were not detected. The results showed water from Nakdong river and Geumho river is contaminated with ESBL-producing E. coli isolates. These results suggest the need for further investigation of antibiotic resistant bacteria to prevent public health impacts in the water environment.
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KEYWORD
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River water, E. coli, Antimicrobial resistance, ESBL, Integron
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