|
KMID : 1023520170400030219
|
|
Korean Journal of Veterinary Service
2017 Volume.40 No. 3 p.219 ~ p.225
|
|
|
Synergistic antibacterial effects of the combination of cephalexin with gentamicin against Staphylococci isolated from dairy cows with clinical mastitis in Gyeongnam province
|
|
Cha Chun-Nam
Yoo Chang-Yeul
Park Eun-Kee
Son Song-Ee
Kim Suk
Lee Hu-Jang
|
|
|
Abstract
|
|
|
|
This study was investigated the synergistic effects from the combination of cefalexin and gentamicin (CCG) against Staphylococcus spp. isolated from bovine milk. Minimum inhibitory concentrations (MICs) and fractional inhibitory concentration (FIC) index were determined for 16 bacteria from 13 bovine farms in Gyeongsangnam province by the National Committee for Clinical Laboratory Standards broth microdilution procedure. Antimicrobial agents tested included cefalexin, gentamicin and CCG. Against Staphylococcus spp. tested, the MIC ranges of cefalexin, gentamicin and CCG were 0.25∼1.0, 0.5∼0.125 and 0.06∼0.125 μg/mL, respectively. In addition, the FIC index ranges of CCG against most of the isolates was 0.28∼0.43 and the FIC index of CCG against 2 strains of Staphylococcus haemolyticus (S. haemolyticus) was 0.59. In conclusion, CCG has a high antibacterial activity against Staphylococcus isolates, then the combination may be applied for the treatment of bovine mastitis caused by Staphylococcus spp.
|
|
|
KEYWORD
|
|
|
Staphylococcus species, Bovine mastitis, Cefalexin, Gentamicin, FIC index
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|