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KMID : 1023520170400040235
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Korean Journal of Veterinary Service
2017 Volume.40 No. 4 p.235 ~ p.244
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The protective efficacy of the enterotoxigenic Escherichia coli vaccine candidate by GI24 against neonatal piglet colibacillosis
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Choi Yeong-Hwan
Moon Ja-Young
Seo Byoung-Joo
Kim Won-Kyung
Cho Jeong-Sang
Choi Min-Su
Lim Jae-Sam
Kim Sung-Bok
Kim Won-Il
Hur Jin
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Abstract
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Enterotoxigenic Escherichia coli (ETEC) strains producing each F4, F5, F6 and F41 fimbriae were lysed by GI24 peptide. The lysate cells were used as ETEC vaccine candidate. This study was carried out to examine whether intramuscular (im) immunization of pregnant sows with the novel vaccine candidate could effectively protect their neonatal piglets against ETEC colibacillosis. All pregnant sows were primed at 11 weeks and were boosted at 14 weeks of pregnancy. Group A sows were im inoculated with PBS. Group B sows were im immunized with 2×109 the mixture. Seral IgG, colostral IgA and IgG titers from group B sows, and seral IgG and IgA levels in group B piglets were significantly higher than those of group A sows and piglets, respectively. After challenge with wild-type ETEC, diarrhea and mortality was not observed in group B piglets. However, diarrhea was observed in 66.7% of group A piglets, and 33.3% mortality was observed. These findings indicate that im immunization of sows with the mixture of the novel vaccine candidate can effectively protect their offspring from ETEC colibacillosis.
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KEYWORD
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Colibacillosis, Enterotoxigenic Escherichia coli (ETEC), Piglets, Protection, Vaccine
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