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KMID : 1023520200430030129
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Korean Journal of Veterinary Service
2020 Volume.43 No. 3 p.129 ~ p.137
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Application of biodegradable metal based drug delivery carrier on Foot and Mouth Disease vaccination in pigs
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Cho A-Ra
Oh Sang-Ik
Choe Chang-Yong
Jung Young-Hun
Do Yoon-Jung
Kim Su-Hee
Choo Hyun-Wook
Gu Jong-Su
Chung Woo-Jin
Cho Sung-Youn
Yoo Jae-Gyu
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Abstract
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In this study, we applied biodegradable drug delivery carries (BDDC) for food-and-mouth (FMD) vaccination. After FMD vaccination using BDDC, we estimated the percentage inhibition (PI) of antibody, decomposed patterns, and histopathologic features of BDDC. PI of antibody was higher than 50 at two weeks after injection and sustained positive PI until 10 weeks after injection. BBDC injection group showed significantly an increased pattern of blood monocyte at two and three weeks after injection. According to the Micro CT, micro-cracks were observed at two weeks after injection and the morphology of BDDC was lost at four weeks after injection. For histopathological examination, acute inflammation with neutrophil infiltration and micro-metallic residues were observed around BDDC until four weeks after injection and inflammatory responses gradually decreased at 10 weeks. Based on our experiment, BDDC is considered as an alternative way to vaccine injection for veterinary applications. Our study can be used as basic data for the drug delivery system using biodegradable metals in the future.
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KEYWORD
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Biodegradable metal, Vaccine injection, Animal application
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