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KMID : 1023520220450010047
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Korean Journal of Veterinary Service
2022 Volume.45 No. 1 p.47 ~ p.54
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Analysis of inflammatory markers in blood related with the occurrence of subcutaneous abscesses in goats
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Ku Ji-Yeong
Park Jun-Hwan
Kim Seon-Ho
Cho Yong-Il
Kim Chan-Lan
Cha Seung-Eon
Park Jin-Ho
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Abstract
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Subcutaneous abscesses, which occur mainly in goats and sheep, are lymph node abscesses caused by Corynebacterium pseudotuberculosis infection, and are divided into internal, external, and mixed types depending on the type of occurrence. While diagnostic methods for subcutaneous abscesses have been continuously studied, research reports for effective treatment and management of subcuta-neous abscesses are inadequate. Therefore, this study was conducted to determine the changes in bio-metric information related to the inflammatory markers of goats induced by subcutaneous abscesses by infection with C. pseudotuberculosis . For this, hematological tests, analysis of inflammatory indi-cators, and analysis of serum proteins through electrophoresis separation of goats with healthy goats and goats inoculated with C. pseudotuberculosis to induce subcutaneous abscesses were compared and analyzed by date, and the differences and characteristics were identified periodically. As a result, in goats induced with subcutaneous abscesses, anemia findings related to a rapid decrease in red blood cell (RBC), hematocrit (HCT), and hemoglobin (Hb) were observed, and a significant increase in inflammatory cells expressed in total white blood cell (WBC), neutrophil, and monocytes was observed. And the levels of acute phase protein (APP) such as fibrinogen, haptoglobin, and serum amyloid A (SAA) were observed to increase rapidly immediately after infection. In addition, in the results of electrophoretic analysis of serum proteins, it was observed that the levels of α-globulin and β-globulin were significantly increased in goats with subcutaneous abscesses. That is, when looking at these changes, it was found that the systemic inflammatory response of goats was rapidly induced immediately after infection with the C. pseudotuberculosis pathogen. Through this study, it was pos-sible to identify changes in the biomarkers of goats with subcutaneous abscesses, which had not been reported. Furthermore, these analyzed data are thoughts to be of great help in identifying, treating, and managing the goats of subcutaneous abscesses.
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KEYWORD
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Goat, Corynebacterium pseudotuberculosis, Subcutaneous abscess, Hematological tests, Analysis of inflammatory indicators
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