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KMID : 1023520230460010093
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Korean Journal of Veterinary Service
2023 Volume.46 No. 1 p.93 ~ p.106
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Genomic epidemiology and surveillance of zoonotic viruses using targeted next-generation sequencing
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Lee Seong-Hyeon
Jeong Myeong-In
Rajoriya Shivani
Puspareni Sara
Kim Won-Keun
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Abstract
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Emerging and re-emerging zoonotic viruses become critical public health, economic, societal, and cultural burdens. The Coronavirus disease-19 (COVID-19) pandemic reveals needs for effective preparedness and responsiveness against the emergence of variants and the next virus outbreak. The targeted next-generation sequencing (NGS) significantly contributes to the acquisition of viral genome sequences directly from clinical specimens. Using this advanced NGS technology, the genomic epidemiology and surveillance play a critical role in identifying of infectious source and origin, tracking of transmission chains and virus evolution, and characterizing the virulence and developing of vaccines during the outbreak. In this review, we highlight the platforms and preparation of targeted NGS for the viral genomics. We also demonstrate the application of this strategy to take advantage of the responsiveness and prevention of emerging zoonotic viruses. This article provides broad and deep insights into the preparedness and responsiveness for the next zoonotic virus outbreak.
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KEYWORD
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Genomic epidemiology, Genomic surveillance, Zoonotic viruses, Targeted next-generation sequencing
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