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KMID : 1023820160080050363
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The Journal of Advanced Prosthodontics
2016 Volume.8 No. 5 p.363 ~ p.371
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Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction
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Doh Re-Mee
Kim Sung-Tae
Keum Ki-Chang
Kim Jun-Won
Shim June-Sung
Jung Han-Sung
Park Kyeong-Mee
Chung Moon-Kyu
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Abstract
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PURPOSE : On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages.
MATERIALS AND METHODS : Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation).
RESULTS : The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study.
CONCLUSION : Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses.
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KEYWORD
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Postoperative radiotherapy, Head and neck cancer, Local irradiation, Implant, Empty lacuna
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