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KMID : 1024620100300020345
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Food Science of Animal Resources
2010 Volume.30 No. 2 p.345 ~ p.350
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Screening of Antiviral Medicinal Plants against Avian Influenza Virus H1N1 for Food Safety
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Lee Jang-Hyun
Nguyen Dinh Van
Jin Yeul Ma
Kim Young-Boong
Kim Soo-Ki
Paik Hyun-Dong
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Abstract
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Various extracts from 30 medicinal plants were evaluated for their antiviral activity against influenza virus A/Puerto Rico/
8/34 (H1N1) and cytotoxicity in MDCK cell culture. The plant material (30 g) was extracted with methanol (300 mL) at
room temperature for 24 h, after which the methanolic extracts were filtered, evaporated, and subsequently lyophilized.
Evaluation of the potential antiviral activity was conducted by a viral replication inhibition test. Among these medicinal
plants, Tussilago farfara, Brassica juncea, Prunus armeniaca, Astragalus membranaceus, Patrinia villosa, and Citrus
unshiu showed marked antiviral activity against influenza virus A/H1N1 at concentrations ranging from 0.15625 mg/mL to
1.25 mg/mL, 0.3125 mg/mL to 10 mg/mL, 5 mg/mL to 10 mg/mL, 0.625 mg/mL to 10 mg/mL, 0.625 mg/mL to 10 mg/mL,
and 0.3125 mg/mL to 5 mg/mL, respectively. The extracts of Tussilago farfara showed cytotoxicity at concentrations
greater than 2.5 mg/mL, whereas the other five main extracts showed no cytotoxicity at concentrations of 10 mg/mL. Taken together, the present results indicated that methanolic extracts of the six main plants might be useful for the treatment of
influenza virus H1N1.
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KEYWORD
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influenza virus H1N1, avian influenza, antiviral activity, medicinal plant, Tussilago farfara, Brassica juncea, Prunus armeniaca, Astragalus membranaceus, Patrinia villosa, Citrus unshiu
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