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KMID : 1024620210410010145
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Food Science of Animal Resources
2021 Volume.41 No. 1 p.145 ~ p.152
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Bioconversion Products of Whey by Lactic Acid Bacteria Exert Anti-Adipogenic Effect
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Lee Ji-Soo
Hyun In-Kyung
Yoon Ji-Won
Seo Hye-Jin
Kang Seok-Seong
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Abstract
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Microbial bioconversion using lactic acid bacteria (LAB) provides several human health benefits. Although whey and whey-derived bioactive compounds can contribute to an improvement in human health, the potential anti-obesity effect of whey bioconversion by LAB has not been well studied. This study aimed to investigate whether bioconversion of whey by Pediococcus pentosaceus KI31 and Lactobacillus sakei KI36 (KI31-W and KI36-W, respectively) inhibits 3T3-L1 preadipocyte differentiation. Both KI31-W and KI36-W reduced intracellular lipid accumulation significantly, without decreasing 3T3-L1 preadipocyte proliferation. In addition, obesity-related transcription factor (peroxisome proliferator-activated receptor γ) and genes (adipocyte fatty acidbinding protein and lipoprotein lipase) were down-regulated significantly in 3T3-L1 cells in the presence of KI31-W and KI36-W. Collectively, these results suggest that bioconversion of whey by LAB exhibits anti-adipogenic activity and may be applied as a therapeutic agent for obesity.
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KEYWORD
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bioconversion, whey, lactic acid bacteria, obesity, 3T3-L1 preadipocyte
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