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We conducted experiment to determine the effect of egg yolk antibodies(EYA) obtained from chickens immunized with fimbrial antigens from ETEC K88 and 987P on growth performance, nutrient digestibility and fecal score in segregated early-weaned pigs. Seventy two early-weaned pigs(5.04±0.09㎏ average body weight and 12 d average age) were blocked by initial weight and then allotted randomly to treatments. Dietary treatments included 1) negative control(NC: basal diet+no antibiotic), 2) positive control(PC: basal diet+0.5% Apralan ^R20), 3) egg yolk antibodies 0.1%(EYA0.1: basal diet+EYA 0.1%), 4) EYA 0.2% (EYA0.2: basal diet+EYA 0.2%), 5) EYA 0.3%(EYA0.3: basal diet+EYA 0.3%) and 6) EYA 0.4%(EYA0.4: basal diet+EYA 0.4%). At day 4 after the onset of the experiment, all pigs were challenged with 1 ㎖ of ETEC K88 and 987P at a dose of 6.0 × 10^(9)cfu ㎖¹and 1.2 x l0^(10)cfu ㎖¹, respectively. At day 2 and 4 after challenging with ETEC K88 and 987P, fecal score(0, nomal; 1, soft feces: 2. mild diarrhea: 3, severe diarrhea) were examined. Pigs fed EYA and PC diets had greater ADG and gain/feed than pigs fed NC diets(P$lt;0.05). Apparent digestibilities of DM and N by pigs fed EYA were not significantly improved compared to pigs fed PC(P$gt;0.05). Pigs fed EYA(fecal score: 0.8) and PC(fecal score: 1.0) tended to decrease the incidence of diarrhea on day 2 after challenging with ETEC K88 and 987P compared to pigs fed NC(fecal score: 1.8). In conclusion, results of this experiment suggest that EYA can be used to replace antibiotic in diets for segregated early-weaned pigs without negative effects on growth performance. nutrient digestibility and fecal score.
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