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KMID : 1025520080500030315
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Journal of Animal Science and Technology
2008 Volume.50 No. 3 p.315 ~ p.320
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Effects of Retinoic Acid on Differentiation of Pig preadipocytes
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Kim Hye-Rim
Chung Chung-Soo
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Abstract
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The current study was undertaken to determine the effects of retinoic acid(RA) on differentiation of pig preadipocyes. Pig preadipocytes were isolated from the backfat of new-born pigs with collagenase digestion. The isolated cells were seeded on MEM/F12 media and washed one day after seeding(day 0). Ten μM RA treated on day 0~2, day 2~4 and day 4~6 decreased differentiation of pig preadipocytes(P<0.01) with the highest inhibition found on day 0~2 treatment. One, 5 and 10μM of RA showed inhibitory action on differentiation in dose-dependent manner. The inhibitory effects of RA on proliferation of pig preadipocytes were smaller, compared to the effects on differentiation.
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KEYWORD
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Retinoic acid, Pig, Preadipocytes, Differentiation
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