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KMID : 1030220110120030171
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Journal of Korean Diabetes
2011 Volume.12 No. 3 p.171 ~ p.173
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A Case of Gabapentin-induced Myoclonus in a Type 2 Diabetic Patient with End-stage Renal Disease
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Choe Eun-Yeong
Lee Byung-Wan
Park Kyeong-Hye
Seok Han-Nah
Kim Da-Ham
Kang Eun-Seok
Cha Bong-Soo
Lee Hyun-Chul
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Abstract
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Development of myoclonus can manifest as a side effect of antiepileptic drugs in subjects with preexisting epilepsy, post-traumatic brain injury, encephalopathy, or focal and multifocal brain lesions. A 69-year-old male showed new onset severe myoclonus and confusion two days after taking 1200 mg gabapentin. The patient had end-stage renal disease secondary to type 2 diabetes and was receiving hemodialysis twice a week. After increasing hemodialysis to three times a week and discontinuing gabapentin, myoclonus spontaneously resolved. Here we report the first case of myoclonus in a Korean subject with diabetic renal failure. We recommend caution in the administration of gabapentin for diabetic subjects with renal disease.
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KEYWORD
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Gabapentin, Myoclonus, Diabetic neuropathies, Chronic renal failure
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