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KMID : 1030220130140030111
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Journal of Korean Diabetes
2013 Volume.14 No. 3 p.111 ~ p.119
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Comparison of DPP-4 Inhibitors
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Kim Nam-Hoon
Kim Sin-Gon
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Abstract
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During past several years, a novel class of antihyperglycemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors, has ecome one of the most important options in the management of type 2 diabetes. These agents have unique insulinotropic actions as well as other advantages such as lower hypoglycemia and a weight-neutral effect compared to traditional insulin secretagogues. To date, 6 different DPP-4 inhibitors have been introduced: sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin and gemiglitin. This review provides a summary of the clinical data for each DPP-4 inhibitor, and discusses the similarities and differences between them.
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KEYWORD
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Dipeptidyl-peptidase IV inhibitors, Incretins, Diabetes mellitus
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