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KMID : 1030220140150030178
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Journal of Korean Diabetes
2014 Volume.15 No. 3 p.178 ~ p.184
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Two Cases of Diabetic Ketoacidosis Associated with Paliperidone Treatment in Schizophrenia
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Kim Hyun-Ho
Yang Hae-Kyung
Ham Hyo-Ju
Jeon Ho-Wook
Lee Joon-Yub
Hwang Sea-Won
Jang Bo-Hyun
Min Gi-June
Lee Jung-Min
Lee Seung-Hwan
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Abstract
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Atypical antipsychotics, which have better efficacy and fewer side effects compared to first-generation antipsychotics, are being used increasingly for the treatment of schizophrenia. However, adverse events such as weight gain, diabetes mellitus and abnormal lipid profile have been reported in patients treated with these agents. Diabetic ketoacidosis (DKA) is a rare side effect of atypical antipsychotics, but deserves attention due to its severity. Although various atypical antipsychotics have been reported as causing DKA, there have been no reports showing an association with DKA and paliperidone, which is a recently developed antipsychotic agent. Here, we report two cases of DKA in patients with paliperidone therapy. Both cases had no history of diabetes before use of paliperidone, and DKA was manifested within 2 years of starting paliperidone therapy. Like other atypical antipsychotics, use of paliperidone warrants monitoring for metabolic derangements including DKA.
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KEYWORD
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Diabetic ketoacidosis, Paliperidone, Schizophrenia
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