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KMID : 1030220220230010021
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Journal of Korean Diabetes
2022 Volume.23 No. 1 p.21 ~ p.27
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Blood Pressure Variability and Diabetes Mellitus
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Jeong Chai-Ho
Sohn Tae-Seo
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Abstract
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Increased blood pressure variability (BPV) has been found to significantly increase the risk of cardiovascular morbidity and mortality in the non-diabetic population. The prognostic importance of increased BPV for the development of micro- and macrovascular complications in type 2 diabetes has been investigated. Type 2 diabetes can increase BPV through different mechanisms, including increased arterial stiffness and autonomic dysfunction. Several studies in type 2 diabetic patients showed inconclusive results regarding all-cause mortality, microvascular complication, and extended major adverse cardiovascular events (MACE). However, some trials showed that BPV might be regarded as a potentially important therapeutic target in the management of type 2 diabetes regarding MACE. For now, the primary goal of antihypertensive treatment in patients with type 2 diabetes shall remain to controll mean blood pressure levels. However, when future studies show consistent results, BPV might be regarded as a therapeutic target in type 2 diabetic patients.
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KEYWORD
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Blood pressure, Cause of death, Diabetes complications, Diabetes mellitus, type 2
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