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KMID : 1030220230240040173
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Journal of Korean Diabetes
2023 Volume.24 No. 4 p.173 ~ p.177
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Anti-Diabetic Medications and Osteoporosis
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Kim Kyong-Young
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Abstract
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Osteoporosis and diabetes mellitus are chronic diseases that are rapidly increasing in our aging society. Several studies have reported that the incidence of osteoporosis and fractures is increased in diabetic patients. Although diabetes itself can affect bone density, anti-diabetic medications can also cause changes in bone mineral density, leading to osteoporosis. It is well known that thiazolidinedione increases the risk of fracture. In comparison, metformin, dipeptidyl peptidase-4 inhibitors, sodium glucose cotransporter 2 inhibitors, and glucagon-like peptide-1 receptor agonists have no significant effect on bone mineral density or fracture risk. Insulin and sulfonylureas should be used cautiously because of the risk of falls associated with hypoglycemia.
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KEYWORD
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Diabetes mellitus, Fractures, bone, Hypoglycemic agents, Osteoporosis
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