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KMID : 1034820190150010049
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Molecular & Cellular Toxicology
2019 Volume.15 No. 1 p.49 ~ p.56
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Chlorin e6 and halogen light as a sebostatic photomedicine modulates linoleic acid-induced lipogenesis
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Ryu A-Reum
Kim Yong-Wan
Lee Mi-Young
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Abstract
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Backgrounds: Chlorin e6-mediated photodynamic therapy (Ce6-PDT) showed anti-microbial and anti-inflammatory effects on acne vulgaris model previously. Excess sebum production in sebocytes is a crucial cause of acne. However, information on the effect of Ce6-PDT associated with lipogenesis in sebocytes has not been reported so far.
Methods: The oil red O staining, triglyceride assay and cholesterol assay were used to investigate lipid synthesis in human sebocytes. The expressions of various molecular signals associated with lipogenesis were examined by western blot analysis.
Results: Ce6-PDT reduced the lipid content of cultured sebocytes. The inactivation of Akt, mTOR, Raptor, PPARγ and C/EBPα, as well as the activation of AMPK, were revealed to be the molecular signals associated with sebostatic modulation by Ce6-PDT.
Conclusion: Ce6-PDT using halogen light exerts antilipogenesis in sebocytes and may be utilized for the treatment of acne vulgaris.
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KEYWORD
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Ce6, Photodynamic therapy, Halogen light, Sebocytes, Anti-lipogenesis
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