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KMID : 1034820190150040407
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Molecular & Cellular Toxicology
2019 Volume.15 No. 4 p.407 ~ p.414
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The protective effects of echinochrome A structural analogs against oxidative stress and doxorubicin in AC16 cardiomyocytes
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Yoon Chang-Shin
Kim Hyoung-Kyu
Mishchenko Natalia P.
Vasileva Elena A.
Fedoreyev Sergey A.
Shestak Olga P.
Balaneva Nadezhda N.
Novikov Vyacheslav L.
Stonik Valentin A.
Han Jin
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Abstract
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Backgrounds: Echinochrome A (6-ethyl-2,3,5,7,8-pen-tahydroxy-1,4-naphthoquinone) is a common naphthoquinone pigment found in the shells, spines, and coelomic fluid of sea urchins. We previously reported that echinochrome A has a cardioprotective function as an antioxidant against reactive oxygen species (ROS) induced by tert-Butyl hydroperoxide and doxorubicin.
Methods: In the current study, we evaluated the antioxidant activity, ATP production, and oxygen consumption rate (OCR) of seven echinochrome structural analogs (spinochromes) in AC16 human cardiomyocyte cells. The compounds included in the study had various substituents including hydroxyl (Sp B and Sp E), amino (Echm A), methoxyl (TriMeEch A), pentyl (No. 284), and hydroxypentyl (No. 285). We also investigated the effects of one dimeric spinochrome (Binaphthoquinone).
Results: Spinochromes exhibited enhanced antioxidant activity and ATP production. Interestingly, the hydroxylated compounds significantly enhanced the OCR and had a cardiomyocyte protective effect in the presence of doxorubicin.
Conclusion: Our findings indicate that echinochrome A structural analogs may have therapeutic potential for cardio-protection.
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KEYWORD
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Echinochrome A, Spinochromes, Structural analogs, Cardioprotective effect, Doxorubicin
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