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KMID : 1034820200160030283
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Molecular & Cellular Toxicology
2020 Volume.16 No. 3 p.283 ~ p.289
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Myricetin induces apoptosis mediated by oxidative stress in 4T1 and E0771 mammary cancer cells
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Knickle Allison
Rasmussen Andrea
Hoskin David W.
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Abstract
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Background: Myricetin is a polyphenolic compound that is cytostatic and/or cytotoxic for several cancer cell types; however, little is known about its effect on mammary carcinoma cells.
Objective: The objective of this study is to determine whether myricetin affects the growth of mammarycarcinoma cells.
Results: Myricetin inhibited the growth of 4T1 and E0771 mouse mammary carcinoma cells to a greater extent than either resveratrol or epigallocatechin-3-gallate, which are also present in red wine and green tea, respectively, and also have anti-cancer activities. Reduced growth of myricetin-treated 4T1 and E0771 cells was the result of apoptosis that was associated with disruption of the outer membrane of mitochondria. Myricetin-induced apoptosis of 4T1 and E0771 cells was prevented by the antioxidant N-acetyl cysteine, indicating that cytotoxicity was the result of oxidative stress caused by the accumulation of reactive oxygen species.
Conclusion: We conclude that the pro-oxidant action of myricetin and ensuing apoptosis of mammary carcinoma cells indicate that myricetin may be useful in breast cancer treatment.
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KEYWORD
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Apoptosis, Flavonoid, Mammary cancer, Myricetin, Reactive oxygen species
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