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KMID : 1034820200160030311
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Molecular & Cellular Toxicology
2020 Volume.16 No. 3 p.311 ~ p.320
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The role of miRNA-155 in monocrotaline-induced pulmonary arterial hypertension through c-Fos/NLRP3/caspase-1
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Chai Shou-Dong
Li Zhen-Kun
Liu Rui
Liu Tao
Dong Ming-Feng
Tang Pei-Zhe
Wang Jian-Tang
Ma Sheng-Jun
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Abstract
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Background: Nisoldipine can effectively suppress pulmonary arterial smooth muscle cell proliferation and c-Fos expression.
Objective: To identify the mechanism of the anti-inflammatory effects in monocrotaline-induced pulmonary arterial hypertension (PAH), focusing on the c-Fos/NLRP3/caspase-1 pathway.
Results: In a mice model of monocrotaline-induced PAH, miRNA-155 expression was increased. In an in vitro model, overexpression of miRNA-155 promoted inflammation and induced c-Fos, NLRP3, and caspase-1 protein expression. The inhibition of c-Fos reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. The inhibition of NLRP3 reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH.
Conclusions: miRNA-155 increased inflammation in monocrotaline-induced PAH through c-Fos/NLRP3/caspase-1.
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KEYWORD
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miRNA-155, Monocrotaline-induced pulmonary arterial hypertension, c-Fos, NLRP3, Caspase-1
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