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KMID : 1035620160040040296
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Allergy Asthma & Respiratory Disease
2016 Volume.4 No. 4 p.296 ~ p.300
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Drug reaction with eosinophilia and systemic symptom induced in a 9-year-old boy
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Song Han-Sol
Choi Woo-Hyeok
Choi Won-Bok
Yang Seung
Hwang Il-Tae
Baek Hye-Sung
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Abstract
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The drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse drug-induced reaction. Acetaminophen is extensively used as an over-the-counter drug as well as a medical therapeutic. In spite of its frequent use, drug eruptions related to DRESS caused by acetaminophen are rare. This case report describes a 9-year-old boy who experienced fever and maculopapular skin rashes after taking acetaminophen. Leukocytosis with marked eosinophilia and slightly elevated levels of liver enzymes were observed. Symptoms resolved after withdrawal of acetaminophen, followed by intravenous methylprednisolone administration. The diagnosis of DRESS induced by acetaminophen was confirmed by an oral challenge test after 2 months. No allergic reactions to ibuprofen were observed.
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KEYWORD
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Drug eruptions, Drug hypersensitivity, Eosinophilia, Acetaminophen
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