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KMID : 1035620240120010003
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Allergy Asthma & Respiratory Disease
2024 Volume.12 No. 1 p.3 ~ p.8
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Allergic rhinitis and hygiene hypothesis
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Jee Hye-Mi
Kim Min-Ji
Kim Hyun-Hee
Kim Hyo-Bin
Rha Yeong-Ho
Park Yang
Sung Myong-Soon
Sheen Youn-Ho
Yum Hye-Yung
Lee Kyung-Suk
Lee Yong-Ju
Chun Yoon-Hong
Choi Bong-Seok
Choi Sun-Hee
Park Yong-Mean
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Abstract
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The hygiene hypothesis, first proposed in 1989, suggested that reduced exposure to infections in early life leads to allergic diseases by the defects in the establishment of immune tolerance. Although many studies provided evidence that some exposure conditions, including family size, antibiotics, probiotics, and viral or bacterial infections, are strongly related to the prevalence of allergic diseases, thereby supporting the hygiene hypothesis, some evidence does not provide acceptable results for the hygiene hypothesis. Further, most studies have focused on patients with asthma or atopic dermatitis, not allergic rhinitis. In this review, we summarize the recent studies for and against the ‘hygiene hypothesis’ and identify causal association with the prevalence of allergic rhinitis.
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KEYWORD
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Allergic rhinitis, Hygiene hypothesis, Allergy
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