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KMID : 1036020150040010007
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지질.동맥경화학회지
2015 Volume.4 No. 1 p.7 ~ p.15
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Effects of the Serum Adiponectin to Tumor Necrosis Factor-α (TNF-α) Ratio on Carotid Intima-Media Thickness in Newly Diagnosed Type 2 Diabetic Patients
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Kim Kwang-Youn
Hong Jung-Ae
Hwang Ha-Won
Lee Sun-Ho
Park Ju-Ri
Yu Sung-Hoon
Kang Jun-Goo
Ryu Ohk-Hyun
Lee Seong-Jin
Hong Eun-Gyoung
Kim Doo-Man
Yoo Jae-Myung
Ihm Sung-Hee
Choi Moon-Gi
Yoo Hyung-Joon
Kim Chul-Sik
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Abstract
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Objectives
Type 2 diabetes, a leading cause of cardiovascular disease, is well known for its association with accelerated atherosclerosis. Adiponectin and tumor necrosis factor - alpha (TNF-α), which are produced and secreted in adipose tissue, have been suggested as predictors for cardiovascular disease. However, little is known about the influence of adiponectin and TNF-α ratio on the progression of carotid atherosclerosis in newly diagnosed type 2 diabetic patients. This study was conducted to evaluate the influence of serum adiponectin/TNF-α levels on the progression of carotid atherosclerosis.
Methods
One hundred eleven newly diagnosed type 2 diabetes patients were enrolled. Anthropometric and biochemical data including serum adiponectin, TNF-α were measured for each participant. Also we measured carotid intima-media thickness (CIMT) at baseline and at 1 year follow-up (n=81). We finally examined the relationship among serum adiponectin over TNF-α levels (ADPN/TNF-α), baseline CIMT, and progression of CIMT at 1 year.
Results
ADPN/TNF-α negatively correlated with baseline CIMT (r=-0.231, p=0.025). Moreover, progression of CIMT was significant at 1 year (0.011±0.138 mm). There was a negative correlation between ADPN/TNF-α and progression of CIMT at 1 year (r=-0.172, p=0.038). In multiple regression analysis, age and HbA1c were found to be independent risk factors for baseline CIMT. However, only HbA1c was an independent risk factor for the progression of CIMT.
Conclusion
ADPN/TNF-α was negatively associated with baseline CIMT and the progression of CIMT at 1 year. Overall glycemic control is the most important factor in the progression of CIMT in patients with type 2 diabetes.
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KEYWORD
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Diabetes Mellitus, Type 2, Adiponectin, TNF-α, Carotid Atherosclerosis, Carotid Intima Media Thickness
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