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KMID : 1037120230410040900
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The World Journal of Men′s Health
2023 Volume.41 No. 4 p.900 ~ p.908
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Can Erectile Dysfunction Severity Predict Major Adverse Cardiovascular Events in Men Undergoing Dialysis? A Prospective Cohort Study
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Naoki Fujita
Masaki Momota
Yusuke Ozaki
Yuki Tobisawa
Tohru Yoneyama
Teppei Okamoto
Hayato Yamamoto
Shingo Hatakeyama
Takahiro Yoneyam
Yasuhiro Hashimoto
Kazuaki Yoshikawa
Chikara Ohyama
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Abstract
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Purpose: To evaluate the impact of severe erectile dysfunction (ED) on future major adverse cardiovascular events (MACE) in men on dialysis.
Materials and Methods: This prospective cohort study included 71 men on dialysis. ED was assessed using the Sexual
Health Inventory for Men (SHIM). Men were divided into the mild/moderate ED (SHIM score ≥8) and severe ED (SHIM score ≤7) groups. The primary endpoint was MACE-free survival. MACE was a composite of myocardial infarction, cardiovascular death, and stroke. The secondary endpoints were cardiac event-free survival and overall survival (OS). Moreover, the predictive abilities of severe ED for 5-year MACE, 5-year cardiac events, and 5-year overall mortality were evaluated.
Results: The median age and follow-up period of the included men were 64 years and 58 months, respectively. The median SHIM score was 4.0; all had a degree of ED, and 64.7% had severe ED. In the background-adjusted multivariable analyses, severe ED was not significantly associated with shorter MACE-free survival (hazard ratio [HR], 1.890; 95% confidence interval [CI], 0.533?6.706; p=0.324), cardiac event-free survival (HR, 2.081; 95% CI, 0.687?6.304; p=0.195), and OS (HR, 0.817; 95% CI, 0.358?1.863; p=0.630). Severe ED did not significantly improve the predictive abilities for 5-year MACE, 5-year cardiac events, and 5-year overall mortality (p=0.110, p=0.101, and p=0.740, respectively).
Conclusions: ED severity was not associated with shorter MACE-free survival, cardiac event-free survival, or OS, and ED severity could not improve the predictive abilities for these outcomes in men undergoing dialysis.
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KEYWORD
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Dialysis, Erectile dysfunction, Major adverse cardiovascular events, Myocardial infarction, Stroke
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