KMID : 1038120190520050464
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Clinical Endoscopy 2019 Volume.52 No. 5 p.464 ~ p.471
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Immunohistochemical Expression of Epithelial-Mesenchymal Transition Markers in Early Gastric Cancer: Cancer Tissue versus Noncancer Tissue
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Jung Hee-Jae
Hong Su-Jin Kim Shin-Hee
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Abstract
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Background/Aims: Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reduced intercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial marker expression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated the immunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues.
Methods: Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection (ESD). We compared the expression level of transforming growth factor (TGF)-¥â, vascular endothelial growth factor (VEGF), E-cadherin, ¥á-smooth muscle actin (¥á-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients, 15 patients had follow-up biopsy at 3 months after ESD for EGC.
Results: Cancer tissues presented higher values of EMT mesenchymal markers (¥á-SMA/vimentin/TGF-¥â/VEGF) than the noncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor location and initial Helicobacter pylori infection.
Conclusions: The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.
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KEYWORD
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Epithelial-mesenchymal transition, Immunohistochemistry, Early gastric cancer, Endoscopic submucosal dissection
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