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KMID : 1038820180210040355
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Pediatric Gastroenterology, Hepatology & Nutrition
2018 Volume.21 No. 4 p.355 ~ p.360
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Fecal Microbiota Transplantation to Patients with Refractory Very Early Onset Ulcerative Colitis
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Yodoshi Toshifumi
Hurt Thomas L.
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Abstract
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Recently, fecal microbiota transplantation (FMT) has been attracting attention as a possible medical treatment of ulcerative colitis (UC). A randomized controlled trial of FMT for children with UC is currently underway. Therapeutic effects of FMT for adults with UC remain controversial. We report two cases of early-onset UC in children. A patient was diagnosed with UC at age 1-year 9-month and underwent FMT at age 2-year 3-month. He attained clinical remission for three weeks after FMT, but then relapsed at four weeks, ultimately undergoing a total colectomy. Another child was diagnosed with UC at 2-year 10-month and she underwent FMT at age 5 years. She has remained in clinical remission following FMT for 24 months and her UC has been maintained without complications with tacrolimus and azathioprine. We report that FMT for early-onset UC appears to be safe and potentially effective.
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KEYWORD
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Fecal microbiota transplantation, Ulcerative colitis, Inflammatory bowel colitis, Colectomy, Gastrointestinal microbiome
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