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KMID : 1039120220110020222
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Clinical and Experimental Vaccine Research
2022 Volume.11 No. 2 p.222 ~ p.225
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Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report
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Herzum Astrid
Trave Ilaria
D’Agostino Federica
Burlando Martina
Cozzani Emanuele
Parodi Aurora
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Abstract
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We present the case of a 24-year-old Caucasian man, who developed a scaly erythematous skin rash after the second dose of coronavirus disease 2019 (COVID-19) vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer; Pfizer, New York, NY, USA) and proved positive for Epstein-Barr virus (EBV) reactivation. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines have been associated with an up-regulated T helper type 1-cell response, possibly favoring an immune system imbalance. Also, EBV reactivation has been postulated after COVID-19 vaccination, but only in the immunosuppressed. Noteworthy we report the first case of EBV viral reactivation associated with cutaneous manifestations in an immunocompetent patient after the COVID-19 vaccine.
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KEYWORD
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COVID-19, COVID-19 vaccine, Epstein-Barr virus, Exanthema, Case report
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