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KMID : 1039120240130010054
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Clinical and Experimental Vaccine Research
2024 Volume.13 No. 1 p.54 ~ p.62
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Monitoring and evaluation of provincial classical swine fever immunization implementation with an E2 subunit vaccine in Jeju Island, South Korea
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Jang Gue-Hwan
Kim Eun-Joo
Cho Seong-Cheol
Moon Sung-Up
Lee Myeong-Hwa
Ko Jin-A
Ko Seung-Bo
Lee Jong-Hoo
Lee Chang-Hee
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Abstract
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Purpose: Accidental vaccination with a live attenuated low-virulence strain of Miyagi (LOM) vaccine led to the reemergence of classical swine fever virus (CSFV) in Jeju province, South Korea in 2014. To control the continual outbreaks of LOM-derived CSFV, the provincial government launched a provincial mass vaccination project using a CSF-E2 subunit vaccine. We conducted this study to assess the herd immunity level and outcomes of E2 vaccine-based immunization in breeding and growing herds on Jeju Island during 2020?2021.
Materials and Methods: A large-scale vaccination trial using the Bayovac CSF-E2 vaccine investigated its efficacy in breeding and growing herds under farm application conditions (10 CSFV-affected and three CSFV-naive swine farms).
Results: The level of herd immunity in each farm was classified into three (S1?S3) and six (G1?G6) profiles in breeding and growing herds, respectively. Immunity monitoring revealed a remarkable improvement in the herd immunity status in all farms. The majority (10/13) of farms, including CSFV-free farms, showed the S1G1 immunity profile in 2021, indicating the appropriate implementation of the advised vaccination regime. Moreover, there were significant decreases in Erns seropositivity from 100% to 50% and 25.9% to 4.3% at farm and pig levels, respectively. In particular, all farms were confirmed as CSFV free in the growing-finishing herds.
Conclusion: Our large-scale trial demonstrated the effectiveness of the E2 subunit vaccine in establishing herd immunity stabilization and eliminating CSFV circulation in the affected farms and highlighted the need for a provincial vaccination policy to regain the CSF-free status on Jeju Island.
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KEYWORD
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Classical swine fever virus, CSF-E2 subunit vaccine, Herd immunity stabilization, Jeju Island, Provincial vaccination
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