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KMID : 1039120240130010063
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Clinical and Experimental Vaccine Research
2024 Volume.13 No. 1 p.63 ~ p.67
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Comparative analysis of antibody responses to BNT162b2, ChAdOx1, and CoronaVac vaccines in the Albanian population over the pandemic years 2021 to 2022
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Genc Sulcebe
Margarita Kurti-Prifti
Erkena Shyti
Jonida Dashi-Pasholli
Fabian Cenko
Alban Ylli
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Abstract
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This repeated cross-sectional study with two independent sample populations compared the antibody response to severe acute respiratory syndrome coronavirus 2 vaccines in Albania in July?August 2021 and 2022. In 2021, it found higher anti-spike-1 seropositivity and antibody levels in fully vaccinated individuals, especially with BNT162b2 and ChAdOx1 and to a lesser degree with CoronaVac. By 2022, all single-dose recipients showed high antibody responses, suggesting natural infection-enhanced immunity. The study indicates a significant evolution in the antibody response to different coronavirus disease 2019 vaccines and suggests that a single vaccine dose, coupled with natural infection, might suffice to maintain adequate immunity levels in an endemic scenario.
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KEYWORD
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SARS-CoV2 antibodies, COVID-19 vaccines, Albanian people, Anti-spike-1 immunoglobulin G, Anti-nucleoprotein immunoglobulin G
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