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KMID : 1039220190290030404
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Journal of Korean Society of Occupational and Environmental Hygiene
2019 Volume.29 No. 3 p.404 ~ p.413
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The Relationship between Malondialdehyde in Exhaled Breath Condensate and Inflammatory Markers in Serum and COPD in Retired Workers Exposed to Mineral Dust
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Lee Jong-Seong
Shin Jae-Hoon
Baek Jin-Ee
Choi Byung-Soon
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Abstract
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Objectives: Chronic obstructive pulmonary disease(COPD) is an important cause of mortality in workers exposed to hazardous dust, such as crystalline silica or coal, and COPD is related to inflammation and oxidative stress in the lung. The aim of this study was to evaluate the association of oxidative stress and inflammation to COPD in retired workers exposed to mineral dust.
Methods: The levels of malondialdehyde(MDA) in EBC as biomarkers for oxidative stress and C-reactive protein(CRP) and lactate dehydrogenase(LD) as biomarkers for inflammation were measured in 107 male subjects(63 pneumoconiosis and 42 COPD subjects).
Results: Mean levels of EBC MDA(2.03 nmol/L vs. 4.65 nmol/L, p=0.010) and serum LD(170.3 U/L vs. 185.9 U/L, p=0.022) were significantly higher in subjects with COPD, but mean levels of serum CRP(p=0.469) did not show a statistical difference between the study groups. Level of EBC MDA was negatively correlated with %FEV1 predicted(r=-0.279, p=0.004) and %FEV1/FVC ratio(r=-0.397, p<0.001).
Conclusions: These results suggest that EBC is a useful biological matrix for investigation of respiratory oxidative stress. High levels of EBC MDA and serum LD are related to COPD in retired workers exposed to mineral dust.
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KEYWORD
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Chronic obstructive pulmonary disease, C-reactive protein, exhaled breath condensate, lactate dehydrogenase, malondialdehyde
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