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KMID : 1039920130200010137
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Neonatal Medicine
2013 Volume.20 No. 1 p.137 ~ p.145
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Growth and Neurodevelopmental Outcomes of Preterm Twins Conceived by In Vitro Fertilization
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Choi Ka-Young
Kim Ee-Kyung
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Abstract
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Purpose: To compare the growth and neurodevelopmental outcomes of preterm twins conceived by in vitro fertilization (IVF) with those naturally conceived.
Methods: We reviewed the electronic medical records of 64 children assessed by K-ASQ (Korean ages & stages questionnaires) at 18 month or 24 month of corrected age. Physical growth was evaluated by Z-scores of weight, length and head circumference at 12 months and 24 months.
Results: Thirty eight (59.4%) preterm twins were the in vitro fertilization group and 26 (40.6%) preterm twins were in the natural conception group. Significantly higher rate of monochorionicity and small for gestational age were detected in the natural conception group (P value=0.001, P value=0.025, respectively). Z scores of weight, length and head circumference were calculated in 56 (87.5%) infants and 51 (79.7%) infants at 12 months and 24 months, respectively. Physical growth did not differ between the two groups. Fifty nine (92.2%) and 40 (65.2%) preterm twins were assessed by K-ASQ at 18 months and 24 months, respectively. There were no significant differences in the rates of cases scored less than -2 standard deviation below the mean in K-ASQ between the IVF and natural conception groups.
Conclusion: Growth and neurodevelopmental outcomes of preterm twins conceived by IVF were comparable with that of naturally conceived preterm twins.
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KEYWORD
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Infant, Premature, Twins, in vitro fertilization, Growth & development
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