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KMID : 1040020230140020039
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International Journal of Pain
2023 Volume.14 No. 2 p.39 ~ p.47
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Animal Models in Osteoarthritis Research: Pain Behavioral Methods and Clinical Significance
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Han Jin
Park Dong-Hwi
Han Seung-Woo
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Abstract
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Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Animal models are required to improve our understanding of the underlying pain mechanisms associated with OA and to evaluate potential therapeutics. In this review, discuss the variety of animal models used in OA research, with a focus on their relevance to human OA and the pain behavioral methods. We discuss commonly used pain behavioral assays, the technical nuances, advantages, and limitations. Moreover, we discuss how these models and methods translate into the clinic by emphasizing any interventions or findings that have guided clinical trials or drug development. Although animal models provide invaluable insight, they still have challenges and controversies, particularly with respect to their true representation of human OA pain as well as ethical considerations. We highlight the need for refining and standardizing pain assessment techniques in animal models and address emerging technologies that promise greater translational significance. This review provides insight into the role of animal models in advancing our understanding of OA pain and paves the way for future research in this field.
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KEYWORD
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animal models, behavioral, osteoarthritis, pain
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