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KMID : 1040320240310010001
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Pediatric Infection & Vaccine
2024 Volume.31 No. 1 p.1 ~ p.11
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Trend in Measles Seroprevalence in the Western Pacific Region: A Systematic Review
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Park Ji-Won
Choe Young-June
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Abstract
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Despite improvements in vaccine coverage, a resurgence of measles has been reported, especially in the infant and adult populations in recent years. We conducted a systematic review of seroprevalence studies conducted in the Western Pacific Region (WPR) to provide insights into seropositivity trends in different countries. This systematic review aimed to collect data from all available measles seroprevalence studies to characterize the differences in population immunity against measles in different countries. We searched the online databases PubMed and Embase to identify: 1) observational studies that investigated seroprevalence in all age groups, and 2) results reported as antibody levels. The following variables were extracted from different study arms: paper identification (title, first author, publication year), inclusion and exclusion criteria, study site, age of subjects, number of subjects, country/area, population, methods, and seropositivity (%). The search yielded a total of 69 studies included in the review. Among the 1?6-year-old group, seropositivity remained relatively high, at 81?100% in China, 86?94% in Korea, and 77?91% in Australia. In adolescents aged 7?18-years old, seropositivity was relatively constant in China and Australia over time; however, a decreasing trend was noted in Korea in 2011 (66%), 2014 (69%), and 2014 (50%) in this age group. A similar downward trend was observed among Korean adults aged 19?39 years in 2011 (74%), 2019 (71%), and 2019 (64%). Children are likely to be protected by universal vaccination programs in WPR countries and regions. However, susceptible individuals with waned immunity may be present among the adult population.
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KEYWORD
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Measles, Seroprevalence, Vaccination, Vaccine
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