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KMID : 1040420180220010017
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Childhood Kidney Diseases
2018 Volume.22 No. 1 p.17 ~ p.21
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The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis
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Lee Keum-Hwa
Yang Jae-Won
Cho Jin-Young
Lee Joo-Yup
Lim Eun-Kyung
Eisenhut Michael
Jeong Dong-Yeon
Steingroever Johanna
Shin Jae-Il
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Abstract
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Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
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KEYWORD
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Thymic stromal lymphopoietin (TSLP), glomerulonephritis, T-helper type 2 (Th2)-dominant immune response, TSLP transgenic mice
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