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KMID : 1040420210250020092
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Childhood Kidney Diseases
2021 Volume.25 No. 2 p.92 ~ p.111
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Biomarkers Predicting Treatment-Response in Nephrotic Syndrome of Children: A Systematic Review
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Lee Ji-Won M.
Ahn Yo-Han
Lim Seon-Hee
Kang Hee-Gyung
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Abstract
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Purpose: Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid-sensitive NS, SSNS), while approximately 10?15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness.
Methods: We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency.
Results : A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required.
Conclusions : The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.
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KEYWORD
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Nephrotic syndrome, Steroid resistant, Biomarker, Treatment, Pediatric
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