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KMID : 1044320170190010054
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Annals of Clinical Neurophysiology
2017 Volume.19 No. 1 p.54 ~ p.57
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Distal acquired demyelinating symmetric neuropathy associated with anti-GM1 and anti-GD1b antibodies
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Ko Keun-Hyuk
Jwa Seung-Joo
Park Sung-Joo
Kang Sa-Yoon
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Abstract
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Distal acquired demyelinating symmetric (DADS) neuropathy is a variant form of chronic inflammatory demyelinating polyradiculoneuropathy. A 54-year-old man presented with gait disturbance owing to weakness in both legs. Nerve conduction studies showed demyelinating sensorimotor polyneuropathy, and laboratory studies demonstrated anti-GM1 and anti-GD1b IgG antibodies, but no anti-myelin associated glycoprotein activity. We suggest that an antiganglioside antibodies assay needs to be applied when DADS neuropathy is suspected in order to improve the classification of dysimmune neuropathies.
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KEYWORD
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Gangliosides, Antibodies, Demyelination, Neuropathy
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