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KMID : 1044720140040010039
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Journal of Lifestyle Medicine
2014 Volume.4 No. 1 p.39 ~ p.46
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Cutaneous Immune Defenses Against Staphylococcus aureus Infections
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Choi Ji-Hae
Seo Ho-Seong
Lim Sang-Young
Park Kyung-Ho
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Abstract
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Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases. Since S. aureus infections occur in an impaired skin barrier, it is important to understand the protective mechanism through cutaneous immune responses against S. aureus infections and the interaction with Staphylococcal virulence factors. In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization. The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.
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KEYWORD
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Staphylococcus aureus, Skin infection, Cutaneous immune system
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