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KMID : 1094720120170010145
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Biotechnology and Bioprocess Engineering
2012 Volume.17 No. 1 p.145 ~ p.159
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Production of a monoclonal antibody by ascites, hollow fiber system, and transgenic plants for vaccine production using CB.Hep-1 mAb as a study case
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Valdes Rodolfo
Tamayo Andres
Gonzalez Marcos
Padilla Sigifredo
Geada Deborah
Ferro William
Mila Lorely
Gomez Leonardo
Aleman Rosario
Leyva Alberto
Garcia Cristina
Mendoza Otto
Alvarez Tatiana
Dorta Lamay
Villega Yanet
Cecilia Dobian
Aragon Hasel
Gonzalez Tatiana
La O Maylin
Lopez Jorge
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Abstract
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Monoclonal antibody (mAb) production methods (ascites, in vitro technologies, transgenic animals, and dicot or monocot transgenic plants; moss, algae) have been improved since they were first developed in 1975. In this study, we illustrate a summary of a study case in which mice, a hollow fiber system, and tobacco transgenic plants were assessed for the production of mAb for vaccine manufacturing and vaccine production.
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KEYWORD
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ascites, hollow fiber bioreactor, plantibody, monoclonal antibody, transgenic plants
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