Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 1094720190240040680
Biotechnology and Bioprocess Engineering
2019 Volume.24 No. 4 p.680 ~ p.686
Characterization of Thermo-sensitive ELP-liposome Complexes According to the Conjugation Manner
Choi Hee-Lak

Won Jong-In
Abstract
Elastin-like polypeptides (ELPs) are thermoresponsive protein-based biopolymers that exhibit phase transition behavior. By conjugating them to the liposome surface, temperature-sensitive ELP-liposome complexes were generated in order to use them as chemotherapeutic agents. In this study, five different ELP-liposome complexes, consisted of three multiple-conjugates and two singleconjugates, were created, and their thermal properties were investigated according to the conjugation manner and ELP length. In addition, changes in the drug release rate from these ELP-liposome complexes caused by variations in both the lysine content and length of ELPs were explored as well.
KEYWORD
Elastin-like polypeptide (ELP), liposome, thermo-sensitive carrier, multi-conjugates, ELP-liposome complex
FullTexts / Linksout information
 
Listed journal information
SCI(E) ÇмúÁøÈïÀç´Ü(KCI)