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KMID : 1094720210260040595
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Biotechnology and Bioprocess Engineering
2021 Volume.26 No. 4 p.595 ~ p.605
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Protective Effects of Titanium Dioxide-based Emulsion after Short-term and Long-term Infrared-A Ray Irradiation on Skin Cells
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Kim Jun-Yeong
Kim Su-Ji
You Ga-Yeon
Choi Eun-Seo
Lee Joo-Hang
Mok Hye-Jung
Lee Jun-Bae
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Abstract
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To accurately evaluate the protective effects of titanium dioxide-based emulsion from infrared-A rays (IRA) irradiation in daily life, we assessed the harmful effects of natural level of IRA irradiation on human skin cells. Using a well-defined solar IRA simulator, short-term (less than seven days) IRA irradiation on fibroblasts at 34°C elicited an increase in the matrix metalloproteinase-1 (MMP1) mRNA level and decrease in the collagen type-1 α-1 (COL1A1) mRNA level. While short-term IRA exposure showed negligible effects on cell proliferation at 34°C, long-term (24 days) IRA irradiation significantly decreased the proliferation of fibroblasts at the same temperature. However, in the presence of heat stress at 43°C, short-term IRA exposure also elicited severe damage including reduction in cell proliferation and procollagen type 1 C-terminal peptide (PIP) level. In addition, formulated titanium dioxide-based emulsion (IRA protective cream; IRC) with an infrared-A protection factor value of ten could successfully protect cells from damage by short-term and long-term IRA exposures. In this study, we demonstrated that IRC reduces mild and severe damages elicited by natural level of IRA irradiation mimicking system after short-term and long-term exposures.
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KEYWORD
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infrared-A ray (IRA), skin aging, cell proliferation, skin cell, emulsion
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