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KMID : 1100120160230010001
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대한골대사학회지
2016 Volume.23 No. 1 p.1 ~ p.7
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The Association between Urine Albumin to Creatinine Ratio and Osteoporosis in Postmenopausal Women with Type 2 Diabetes
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Lee Ye-Yeon
Kim Han-Byul
Lee Jong-Won
Lee Gyu-Min
Kim Sang-Yoon
Hur Ji-An
Cho Ho-Chan
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Abstract
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Background: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about the relationship between end-stage renal disease and osteoporosis, research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking.
Methods: We assessed 91 postmenopausal women with type 2 diabetes who visited our hospital from January 2009 to January 2012.
Results: Among 91 patients, the prevalence of osteoporosis and osteopenia was 35.2% (32 cases) and 32.9% (30 cases) according to bone mineral density. The patients with microalbuminuria and macroalbuminuria (urine albumin-to-creatinine ratio [UACR] ≥ 30) had a significantly higher incidence of osteoporosis compared to subjects with normoalbuminuria (P<0.05).
Conclusions: This study indicates that UACR may be a useful biomarker for increased risk of osteoporosis in postmenopausal women with type 2 diabetes who have been linked to higher UACR levels.
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KEYWORD
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Albumins, Creatinine, Diabetes mellitus type 2, Osteoporosis postmenopausal
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