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KMID : 1100120160230030121
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대한골대사학회지
2016 Volume.23 No. 3 p.121 ~ p.127
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Current Status and Strategy of microRNA Research for Cartilage Development and Osteoarthritis Pathogenesis
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Asahara Hiroshi
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Abstract
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MicroRNAs (miRNAs), which are small (~21 nucleotides) non-coding RNAs, are important players in endochondral ossification, articular cartilage homeostasis, and arthritis pathogenesis. Comprehensive and genetic analyses of cartilage-specific or cartilage-related miRNAs have provided new information on cartilage development, homeostasis, and related diseases. State-of-the-art combinatorial approaches, including transcription-activator like effector nuclease (TALEN)/clustered regularly interspaced short palindromic repeats (CRISPR) technique for targeting miRNAs and high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation for identifying target messenger RNAs, should be used to determine complex miRNA networks and miRNA-dependent cartilage regulation. Use of advanced drug delivery systems involving cartilage-specific miRNAs will accelerate the application of these new findings in arthritis therapy.
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KEYWORD
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Cartilage, Chondrocytes, MicroRNAs, Osteoarthritis
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