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KMID : 1100120180250020065
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대한골대사학회지
2018 Volume.25 No. 2 p.65 ~ p.72
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Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint
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van der Kraan Peter M.
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Abstract
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Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-β is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-β are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-β, the function of TGF-β is strikingly different in normal and OA joints. The consequences of this difference in TGF-β levels on joint homeostasis and pathological changes in OA joints are discussed in this review.
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KEYWORD
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Cytokines, Osteoarthritis, Transforming growth factor beta
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