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KMID : 1100120190260010031
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대한골대사학회지
2019 Volume.26 No. 1 p.31 ~ p.38
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Effects of Thyrotropin Suppression on Bone Health in Menopausal Women with Total Thyroidectomy
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Kim Eun-Heui
Jeon Yun-Kyung
Pak Kyoung-June
Kim In-Joo
Kim Seong-Jang
Shin Seung-Hyeon
Kim Bo-Hyun
Kim Sang-Soo
Lee Byung-Joo
Lee Jeong-Gyu
Goh Tae-Sik
Kim Keun-Young
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Abstract
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Background: This study examined the change in the trabecular bone score (TBS), areal bone mineral density (aBMD), and osteoporosis in postmenopausal women who underwent thyrotropin (TSH)-suppressive therapy for treating papillary thyroid cancer after a total thyroidectomy procedure.
Methods: We evaluated 36 postmenopausal women who received a total thyroidectomy for papillary thyroid cancer and were undergoing TSH suppressive therapy with levothyroxine. Postmenopausal women (n=94) matched for age and body mass index were recruited as healthy controls. The aBMD and TBS of the lumbar spine were compared between dual energy X-ray absorptiometry (DXA) at baseline and at follow-up after an average of 4.92 years.
Results: There was no significant difference in the rate of diagnoses of osteoporosis, osteopenia, or normal bone status between the 2 groups during the baseline DXA evaluation. However, the TBS was significantly lower whereas aBMD did not show significant difference at the time of baseline DXA measurement (1st DXA, 1.343±0.098 vs. 1.372±0.06317, P<0.001; 2nd DXA, 1.342±0.095 vs. 1.370±0.062, P<0.001). The TBS and aBMD did not differ significantly between the initial and follow-up DXA images in both groups of TSH suppressive patients and controls.
Conclusions: The average value of TBS and aBMD did not significantly change during the follow-up period. The TSH suppressive therapy was revealed as not a significant factor for the progressive deterioration of bone status during long term follow-up.
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KEYWORD
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Absorptiometry, photon, Bone density, Postmenopause, Thyroid neoplasms
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