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KMID : 1100220040030010048
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Dementia and Neurocognitive Disorders
2004 Volume.3 No. 1 p.48 ~ p.54
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Tc-99m HMPAO SPECT Findings Using Statistical Parametric Mapping Analysis in Alzheimer´s Disease and Vascular Dementia
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Park Kyung-Won
Kang Do-Young
Kim Eung-Gyu
Kim Sang-Ho
Kim Jae-Woo
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Abstract
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Background: Functional neuroimaging of single photon emission computed tomography (SPECT) has been used to diagnose or to define the pathophysiological mechaniems of dementias. The purpose of this study was to assess the specific patterns and the differences of regional cerebral blood flow(rCBF) in the patients with Alzheimer´s disease (AD) and vascular dementia (VD) using Tc-99m HMPAO SPECT.
Methods: fifty five AD, 34VD and 30 normal control subjects participated in this study. Patients with VD and AD were matched for age and clinical dementia rating scores. Three group were evaluated with Tc-99m HMPAO SPECT for measuring rCBF. Statistical parametric mapping(SPM) software was used for analysis of SPECT image data. The SPECT data in the patients with AD and VD were compared with the normal control subjects and then compared with each other.
Result: SPM analysis of the SPECT image showed significant perfusion deficits in the bilateral frontotemporal regions in the patients with AD and in the bilateral frontotemporopariental regions in the patients with VD compared with normal control subjects (uncorrected p<0.001). AD patients, compared to VD patients, revealed significant hypoperfusion in the bilateral frontal areas, left middle temporal gyrus, right fusiform gyrus, right precuneus and right significant hypoperfusion in the bilateral thalami, left insula, bilateral postcentral gyri, right cuneus, right cingulate gyrus and bilateral frontal subcortical regions (uncorrected p<0.01). VD patients, compared to AD patients, revealed significant hypoperfusion in the bilateral thalami, left insula, bilateral postcentral gyri, right cingulate gyrus and bilateral frontal subcortical regions (uncorrected p<0.01)
Conclusions: Our study shows the characteristics and patterns of perfusion deficits in AD and VD patients, and defines the specific areas of hypoperfusion in these two demensias.
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KEYWORD
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Alzheimer´s Disease, Vascular Dementia, Statistical Parametric Mapping, SPECT
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